病理学第14章炎症.ppt

This is a caseating granuloma. Epithelioid cells surround a central area of necrosis that appears irregular, amorphous, and pink. Grossly, areas of caseation appear cheese-like. Granuloma, HE, showing Langhans giant cells. These multinucleated cells have macrophage markers on their cell surface, and are apparently the result of fusion of individual macrophages. While useful in diagnosing a granuloma, they are not considered the characteristic cell. That honor belongs to the epitheliod histiocyte, which also has macrophage cell surface markers. Giant cells are a committee of epithelioid macroph