光学活性芳族氨酵的合成及其稳定性的研究-上海有机化学研究所.PDF

有机化学 YOUJI HUAXUE , 1990 , 10, 464470 研究简报 光学活性芳族氨酵的合成及其稳定性的研究 童跃i生、丁孟贤* o扫因科学院民杏出用化学研究所，吉林，长春， 130022) Synthesis of OpticalIy Active Cyanohydrins and Study on Their Sta- bUities TONG Yue-Jin , DING Meng-Xian* (Changchun Institute df App 1ied Chemistry, Chinèse Academy 01 Sciences, 130022 Changchun , Jilin) Abstract: Twenty chiral catalysts , among which twelve were prepared or purified in this work. have been used in the asymmetric synthesis of cyanohydrins from benzaldehyde. The activity and enantioselectivity of these catalysts in the reaction have been ohserved. The Op- tical yíelds of these asymmetric reaction varied from zero to about 60%. The investigation on the stabíIity of the cyanohydrins showed that the purified cyanohydrins could be opti- cally stable within a week without apparent decrease of their optical rotation and chemi- cally stable over 5 months. The mechanism of the reaction and the evaluation of enantio- selectivity of the catalysts have 81so been discussed. Dellcriptof: asymmetric synthesis. optically active catalyst. optically active cyanohydrin. stability 光学活性芳族有t 醇以及由它转变而成的α­ 立体选择能力的评价以及寄:醇的旋光稳定性和 瓷基酸、 α一起基阳、 α-f.至;基阳和自-瓷基胶等 化学稳定性等与氧醉不对称合成紧密相关的问 光学活性异构体都是重要的农药和医药巾间 题至今尚较少涉及，值得深入研究。 休，从实用观点苔，利用僵化不对称合成米击1] 禀 瞌 取光活性缸醉，更具有重要意义。近年来，环 状二肤 CycIo[L( D )-Phe--L( D )-His] 用于催化 熔点测定用 RY-l 型仪，温度计未经校正。 芳族氧胖的不对称合成，由于具有与 D-捏腊 脱光度用 PEKIN-ELMER-241 型仪测定，测 0 酶相类似的rfS ?r5性和高对映选择性[1.汀，尤为 量精度为土0.001 1106 型仪测 。元素分析用