PPARa基因V227A多态性的-研究早发2型糖尿病的相关性的-研究.pdfVIP

TheassociationsofV227A ofthePPAR polymorphismalpha with 2diabetesmeilitus gene early—-onsetType Abstract thecorrelationsofPPARaV227Ain Objective：Toexplore polyphismearly-onset indalianofChina． T2DM Methods：Atotalof menand252 were enrolled 496(244 women)T2DMsubjects and dividedintotwo andlate—onset whichWeredefinedas groups：early-onsetgroups and40 menand80 al茎40 diagnosed old．Early-onsetT2DMsubjects206(126 years was36．334-4．02old．Late-onset 18men women)averageage years T2DM 290(1 subjects and172 was56．36a：9．56 old．Normalcontrol women)averageage years groupsubjects were of248 12menand136 composedhealthypeople(1 women)．Extmctedperipheral bloodwhitebloodcell DNAto detectPPARaV227A genomic was todetectthePPARaV227A polymoIphism．PCR-directemployed gene sequencing mutationintwo of andallele and were the groupsfrequenciesgenotype observed，and clinicalcharacteristicsofmutationcarrierswere gene investigated． Resuits：(!)The fastingplasmaglucoSeffPGgtriglyceride(TG)，uricacid(UA) were in than