《药物化学研究进展论文》-毕业论文.docVIP

PAGE l 药物化学研究进展 摘 要 药物化学是以药物的开发为最终目的的，目前对药物开发主要集中在先导化合物（或活性化合物）开发和药物的产业化。比较分子场分析方法和高通量药物筛选是先导化合物的设计与筛选的方法，本文主要通过对比较分子场分析方法和高通量药物筛选技术的介绍来说明药物的开发。最后分别介绍了抗癌药、大环内酯类抗生素、非常规精神病药物以及抗艾滋病药物的研究状况并对最新代表药物的结构、作用机制、理化性质、药代动力学性质、临床应用及副作用等做了较详细的分析。 关键词：比较分子场分析方法，高通量药物筛选，植物来源抗癌药，大环内酯类抗生素，非常规精神病药物，抗艾滋病药物 PROGRESS IN MEDICINAL CHEMISTRY ABSTRACT The ultimate goal of Medicinal chemistry is drug development，At present，Drug development mainly concentrated in the development of lead compounds (or activity compounds) and industrialization of the drug. Comparative molecular field analysis and high-throughput screening are designed and screening lead compounds methods, The paper mainly illustrates the introduction of drug development by comparative molecular field analysis and high-throughput screening technology. At last the paper introduces the situation of the study of anti-cancer drugs, macrolide antibiotics, atypical antipsychiatric agents and Anti-AIDS drug. And made a full analysis on the newest representative drugs’structure, mechanism, physical and chemical properties, the nature of the pharmacokinetics, clinical applications and side effects And so on. KEY WORDS:Comparative molecular field analysis，high-throughput screening ,anti-cancer drugs，macrolide antibiotics，atypical antipsychiatric agents，Anti-AIDS drug. 目录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc485789158 摘 要 PAGEREF _Toc485789158 \h I HYPERLINK \l _Toc485789159 ABSTRACT PAGEREF _Toc485789159 \h II HYPERLINK \l _Toc485789160 前言 PAGEREF _Toc485789160 \h 1 HYPERLINK \l _Toc485789161 第一章药物化学的研究进展的选题与意义 PAGEREF _Toc485789161 \h 2 HYPERLINK \l _Toc485789162 1.1当前药物化学研究的国际形势 PAGEREF _Toc485789162 \h 2 HYPERLINK \l _Toc485789163 1.2选题意义 PAGEREF _Toc485789163 \h 2 HYPERLINK \l _Toc485789164 第二章新药研究的两个方法 PAGEREF _Toc485789164 \h 4 HYPERLINK \l _Toc485789165 2.1药物发现新策略——高通量虚拟筛选 PAGEREF _Toc485789165 \h 4 HYPERLINK \l _Toc485789166 2.1.1计算机辅助药物分子设计的现状和展望 PAGEREF _Toc485789166 \h 4 HYPERLINK \l _Toc485789167 2.1.