小细胞肺癌诊断疗进展r.pptVIP

Small Cell Lung Cancer (SCLC):Diagnosis, Treatment and Natural History Gary L.Weinstein M.D. SCLC Lung cancer epidemiology SCLC Pathology Tumor markers Genetics Clinical course Staging Treatment SCLC, factoids 15 – 25 % of all lung cancers Almost exclusively in smokers Distinguished from NSCLC by: Rapid doubling time High growth fraction Early development of wide-spread mets SCLC, factoids (cont’d) Considered highly responsive to “chems and beams” BUT…usually relapses within 2 years despite treatment Overall, only 3 –8 % of all patients survive more than 5 years Most common malignancy assoc