泮托拉唑治疗消化性溃疡合并出血疗效剖析2.docVIP

泮托拉唑治疗消化性溃疡合并出血疗效剖析2 　　【摘要】 目的 探讨泮托拉唑治疗消化性溃疡合并出血的临床效果。方法 100例消化性溃疡合并出血患者， 随机分为观察组和对照组， 各50例。两组均给予常规治疗， 对照组患者给予奥美拉唑治疗， 观察组患者给予泮托拉唑治疗。评定两组治疗效果， 观察不良反应发生情况。结果 观察组治疗后的临床效果总有效率为96.0%， 对照组治疗后的总有效率为78.0%， 观察组总有效率高于对照组， 差异有统计学意义（P0.05）。观察组不良反应发生率（8.0%）低于对照组（32.0%）， 差异有统计学意义（P0.05）。结论 泮托拉唑治疗消化性溃疡合并出血疗效显著， 用药安全， 值得借鉴。 　　【关键词】 消化性溃疡；出血；泮托拉唑 　　DOI：10.14163/j.cnki.11-5547/r.2015.18.039 　　Analysis of curative effect by pantoprazole in the treatment of peptic ulcer complicated with hemorrhage LI Mei-li. Enping City People’s Hospital， Enping 529400， China 　　【Abstract】 Objective To investigate the clinical effect of pantoprazole in the treatment of peptic ulcer complicated with hemorrhage. Methods A total of 100 peptic ulcer complicated with hemorrhage patients were randomly divided into observation group and control group， with 50 cases in each group. Both groups received conventional treatment， and the control group received omeprazole， while the observation group received pantoprazole. Curative effects and incidences of adverse reactions were evaluated in the two groups. Results After treatment， the observation group had total effective rate as 96.0%， and the control group had that as 78.0%. The observation group had higher total effective rate than the control group， and their difference had statistical significance （P0.05）. Incidence of adverse reactions was lower in the observation group （8.0%） than the control group （32.0%）， and their difference had statistical significance （P0.05）. Conclusion Pantoprazole provides precise effect in treating peptic ulcer complicated with hemorrhage. It is safe and worthy of reference. 　　【Keywords】 Peptic ulcer； Hemorrhage； Pantoprazole 　　消化性溃疡属于慢性消化系统疾病， 消化性溃疡主要指胃溃疡和十二指肠溃疡， 溃疡形成机制与消化道黏膜的防护因素和攻击因素失衡有关， 如胃酸分泌过多、幽门螺杆菌等因素均可导致溃疡形成。在消化性溃疡的病程中可合并出血， 需要临床及时止血治疗， 出血量较多的可危及到患者生命。在止血治疗措施中， 抑制胃酸分泌的药物应用提高了消化性溃疡合并出血的止血效果。本文选择本院消化性溃疡合并出血患者， 观察泮托拉唑对此类患者的治疗效果。现报告如下。 　　1 资料与方法 　　1. 1 一般资料 入选的100例消化性溃疡合并出血患者均为本院2011年11月～2014年11月期间收治病例， 患者均符合消化性溃疡诊断标准[