泮托拉唑治疗消化性溃疡合并出血疗效剖析.docVIP

泮托拉唑治疗消化性溃疡合并出血疗效剖析 　　【摘要】 目的 探讨泮托拉唑治疗消化性溃疡合并出血的临床疗效。方法 60例消化性溃疡合并出血患者， 随机分为观察组和对照组， 各30例。观察组给予泮托拉唑治疗， 对照组给予奥美拉唑治疗， 比较两组治疗效果及不良反应情况。结果 观察组总有效率为93.3%， 对照组总有效率为90.0%；两组比较差异无统计学意义（P0.05）。观察组不良反应发生率6.7%低于对照组的30.0%， 差异有统计学意义（P0.05）。结论 泮托拉唑治疗消化性溃疡合并出血疗效显著， 不良反应较少， 值得借鉴。 　　【关键词】 消化性溃疡；出血；泮托拉唑；奥美拉唑 　　DOI：10.14163/j.cnki.11-5547/r.2015.18.027 　　Analysis of curative effect by pantoprazole in the treatment of peptic ulcer complicated with hemorrhage ZENG De-ying， YANG Xin-kui， QIN Shan-jun， et al. Department of Gastroenterology， Guangdong Zhongshan City Chen Xing-hai Hospital， Zhongshan 528415， China 　　【Abstract】 Objective To investigate the clinical effect of pantoprazole in the treatment of peptic ulcer complicated with hemorrhage. Methods A total of 60 peptic ulcer complicated with hemorrhage patients were randomly divided into observation group and control group， and each group received 30 cases. The observation group received pantoprazole for treatment， and the control group received omeprazole. Curative effects and adverse reactions were compared in the two groups. Results The observation group had total effective rate as 93.3%， and that of the control group was 90.0%. Their difference had no statistical significance （P0.05）. The observation group had lower incidence of adverse reactions as 6.7% than 30.0% of the control group， and their difference had statistical significance （P0.05）. Conclusion Pantoprazole provides precise effect with few adverse reactions in treating peptic ulcer complicated with hemorrhage， and it is worthy of referring. 　　【Key words】 Peptic ulcer； Hemorrhage； Pantoprazole； Omeprazole 　　消化性溃疡是常见的胃肠道慢性疾病， 可反复发作， 导致患者生存质量严重下降。消化性溃疡病程中可并发出血， 引起上消化道出血， 患者可有呕血、黑便等症状， 出血严重患者可引起失血性休克， 危及患者生命。消化性溃疡合并出血的治疗措施， 抑制胃酸分泌药物的应用有助于提高止血效果， 研究表明质子泵抑制剂在抑制胃酸方面治疗消化性溃疡的临床效果较高。本文选择本院30例患者观察泮托拉唑在消化性溃疡合并出血中的治疗效果。现报告如下。 　　1 资料与方法 　　1. 1 一般资料 入选的消化性溃疡合并出血（符合消化性溃疡诊断标准[1]）患者共60例（均为本院2011年1月～ 2014年12月收治）， 所选患者合并有出血症状， 患者表现为呕血、黑便、头晕、心悸、乏力等症状， 同时排除消化性溃疡合并穿孔患者、幽门梗阻患者， 所选患者