《Hp致病因子与相关疾病研究进展》》-毕业论文.docVIP

PAGE 精品 学号： 毕业生高级选修、回归基础实习论文 题 目： Hp致病因子与相关疾病研究进展 学生姓名： 指导教师： 目 录 中文摘要……………………4 英文摘要……………………4 综述正文……………………6 参考文献……………………9 附录…………………………10 谢辞…………………………11 个人简介……………………12 Hp致病因子与相关疾病研究进展 摘 要 Hp(Helicobacter pylori,Hp)是一种定植于人体胃黏膜，并引起不同胃十二指肠疾病的革兰阴性细菌。Hp感染可引起慢性胃炎、胃十二指肠溃疡，研究结果表明，Hp(+)患者胃窦部炎症活动性显著重于Hp(-)患者。业已证实Hp感染是慢性活动性胃炎的主要病因，也是两种疑为癌前病变萎缩性胃炎、肠上皮化生的重要病因和促进因素。众多回顾性与前瞻性的流行病学研究显示，Hp感染与胃癌发生相关。Hp于1994年被世界卫生组织国际癌症研究机构(IARC)列为人类Ⅰ类致癌原。不同疾病是由Hp和宿主之间复杂的致病机制导致. 近年来, 学者们对Hp毒力致病因子的研究取得了长足进展, 为揭开Hp感染的致病机制奠定了基础. 本文就Hp毒力致病因子CagA、VacA、BabA、OipA等以及Hp所致的相关疾病的最新研究进展进行了综述. 关 键 词 Hp，毒力因子，致病，相关疾病 Abstract Helicobacter pylori (Helicobacter pylori, Hp) is a kind of colonization in human gastric mucosa, and various gastroduodenal diseases caused by gram-negative bacteria. Helicobacter pylori infection can cause chronic gastritis, gastric ulcer, the results show that, Hp (+) activity in patients with antral inflammation was focused on the Hp (-) patients. Helicobacter pylori infection has been confirmed chronic active gastritis is the major cause is two suspected precancerous lesions atrophic gastritis, intestinal metaplasia of the major causes and contributing factor. Numerous retrospective and prospective epidemiological studies have shown that Helicobacter pylori infection and gastric cancer-related. Helicobacter pylori in 1994 by the World Health Organization IARC (IARC) as human class Ⅰ carcinogen. Different disease is caused by Hp and host pathogenic mechanism leading to the complex. In recent years, scholars of the Hp virulence factors of pathogenic made considerable progress, in order to reveal the pathogenic mechanism of Hp infection in the foundation . This article pathogenic Hp virulence factor CagA, VacA, BabA, OipA, Hp and other diagnostic techniques and the latest research are reviewed. Key words Helicobacter pylori, virulence factors, pathogenesis，related disease 一、Hp的致病因子 1. ure 尿素酶 Hp一个重要的生物学特征就是可以分泌大量尿素酶, 尿素酶的功能