annexin 1 induced by anti-inflammatory drugs binds to nf-κb inhibiting its activation anticancer effects should in vitro and in vivo.pdf
- 1、本文档共20页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
annexin 1 induced by anti-inflammatory drugs binds to nf-κb inhibiting its activation anticancer effects should in vitro and in vivo
NIH Public Access
Author Manuscript
Cancer Res. Author manuscript; available in PMC 2011 March 15.
N
Published in final edited form as:
I
H
Cancer Res. 2010 March 15; 70(6): 2379–2388. doi:10.1158/0008-5472.CAN-09-4204.
-
P
A
A
u Annexin 1 induced by anti-inflammatory drugs binds to NF-κB
t
h
o
r
inhibiting its activation: Anticancer effects in vitro and in vivo
M
a
n
u Zhiquan Zhang, Liqun Huang, Wenping Zhao, and Basil Rigas
s
c Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY
r
i
p
11794-8173, USA
t
Abstract
Annexin A1 (ANXA1), a mediator of the anti-inflammatory action of glucocorticoids, is important
in cancer development and progression, whereas NF-κB regulates multiple cellular phenomena,
some of them associated with inflammation and cancer. We demonstrated that glucocorticoids and
the chemopreventive modified NSAIDs, such as nitric oxide donating aspirin (NO-ASA) and
N phospho-aspirin, induced ANXA1 in cultured human colon and pancreatic cancer cells. ANXA1
I
H associated with NF-κB and suppressed its transcriptional activity by preventing NF-κB binding to
-
P DNA. The induction of ANXA1 by glucocorticoids was proportional to their anti-inflammatory
A
A
potency, as was the suppression of NF-κB activity, which was accompanied by enhanced
u apoptosis and inhibition of cell growth mediated by changes in NF-κB-dependent cell signaling.
t
h The proposed novel mechanism was operational in the intestinal mucosa of mice treated with
o
r
dexameth
您可能关注的文档
- 8876金蝶财务软件免费版_用友u8财务软件金蝶财务软件erp.doc
- a framework for classification of non-linear loads in smart grids using artificial neural networks and multi-agent systems:基于人工神经网络和多智能体系统的智能电网非线性负荷分类框架.pdf
- 600399 抚顺特钢 汽车用钢行业不锈钢棒材行业工模具钢行业.doc
- a multi-attribute utility decision analysis for treatment:一种用于治疗的多属性效用决策分析.pdf
- 8000中文使用手冊.pdf
- A White Heron (一只白色的苍鹭).doc.doc
- a1t__考研必备-概率论与数理统计公式整理(全).pdf
- AAC_1106_机坪运行安全与事故预防(PPT 66页).ppt
- AA`天津宝洁公司福利手册.doc
- Abaqus 6.10 安装指南 - Jincheng的日志 - 网易博客.pdf
最近下载
- 2023年河西学院药学《药理学》科目期末试卷A(有答案).docx VIP
- 2023年海南师范大学体育教育专业《普通心理学》期末试卷A(有答案).docx VIP
- 2024年国开电大本科《流通概论》单项多项选择题库(附答案).pdf
- 2023年海南师范大学地理科学专业《普通心理学》期末试卷A(有答案).docx VIP
- 精品解析:广东省广州市黄埔区2022--2023学年七年级下学期期末考数学试题(解析版).docx VIP
- 企业安全生产费用提取和使用管理办法(课件).pptx
- 系统接口对接实施方案.docx VIP
- 2023年海南师范大学物理学专业《普通心理学》期末试卷A(有答案).docx VIP
- 2021智慧树答案【思想道德修养与法律基础(山东师范大学)】智慧树网课章节测试答案 .doc
- 商汤科技上市招股说明书.pdf
文档评论(0)