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SQUAMOUS-CELL EPITHELIOMA tendency to differentiate, or at least very little, there
are many mitotic figures.
OF THE LIP In studyin these epitheliomas, therefore, it occurred
A STUDY OF FIVE HUNDRED AND to me that they should be graded accordin to differen¬
THIRTY-SEVEN CASES tiation and mitosis, special stress bein laid on the
former. The gradin was made on a basis of 1 to 4
A. C. BRODERS, M.D. and absolutely independent of the clinical history. H
ROCHESTER, MINN. an epithelioma shows a marked tendency to differen¬
tiate, that is, if about three fourths of its structure is
Of all the malignant neoplasms with which man is differentiated epithelium and one fourth undifferen-
afflicted, few cause more concern and inconvenience tiated, it is graded 1 ; if the differentiated and undif-
than that of epithelioma of the lip. In the past, pathol- ferentiated epithelium are about equal, it is graded 2 ;
ogists have been content to classify cancer of the lip as if the undifferentiated epithelium forms about three
cancer, without any
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