大鼠黑质Orexin的电生理效应与其与帕金森病关系的实验-研究.pdf

GABAergicneurons(normalrats：PO．01，Parkinsonian for was in OXl observedthesubstantia immunolabelingreceptors nigra parscompacta andreticulataofbothnormaland6一OHDA rats．Conclusion：Thein parkinsonian present vivo studies evidencethatorexin—A excitationon electrophysiologicalprovided produced thesubatantia 0X1 areinvolvedinthemodulation nigraneurons．Endogenousreceptors of ofboth and neurons．Orexin—Aalso activity firing dopaminergicGABAergic produced excitationin6一OHDA showed parkinsonianrats．Finally,immunostainingpositive of inthesubstantiaofbothnormaland rats． 0XIreceptors expression nigra parkinsonian 111e arationaleforfurther intothe present may findingsprovide investigations involvementorexin inParkinson’Sdisease． ofnigralsystem student：Ziran Postgraduate Liu(Neurobiology) DirectedProfiLeiChen by Keywords：Orexin；substantia nigraparseompacta；substantianigraparsrefieulata； Parkinson’S disease；extracellular recordings 目录 引言…………………………………………………………………………………………1 第一章实验材料…………………………………………………………………………～3 1．1实验动物………………………………………………………………………………‘3 1．2药品及配制……………………………………………………………………………‘3 1．3主要实验仪器…………………………………………………………………………3 第二章实验项目及方法…………………………………………………………………“5 2．1