老年Ⅰ期周围型非小细胞肺癌大分割三维适形放射治疗疗效剖析.docVIP

老年Ⅰ期周围型非小细胞肺癌大分割三维适形放射治疗疗效剖析 　　摘要：目的 探讨大分割三维适形放射（3DCRT）治疗老年周围型非小细胞肺癌的疗效及毒性反应。方法 32例老年Ⅰ期周围型非小细胞肺癌（NSCLC）随机分成三维适形大分割放疗组和常规分割放疗组。其中大分割放疗组15例，处方剂量DT 48～60 Gy，3～6 Gy/次，5次/w；常规分割放疗组17例，处方剂量DT 66 Gy，2 Gy/次，5次/w。结果 大分割放疗组和常规分割放疗组完全缓解（CR）率分别为40.00%、17.70%，部分缓解（PR）率分别为46.70%、23.50%，有效率（CR+PR）分别为86.70%、41.20%（P0.05）；1、2、3年生存率大分割放疗组分别为80.00%、53.30%、33.30%，常规分割放疗组分别为47.10%、23.50%、17.60%。放射性食管炎和放射性肺炎发生率相当。结论 大分割三维适形放疗治疗老年Ⅰ期周围型非小细胞肺癌的效果优于常规分割放疗，且不良反应相当。 　　关键词：非小细胞肺癌；周围型；放射治疗；预后 　　中图分类号：R734.2 文献标识码：A 文章编号：1006-1959（2017）23-0044-02 　　Analysis of Curative Effect of Three Dimensional Conformal Radiotherapy for Elderly Patients with Stage I Peripheral non-small Cell Lung Cancer 　　CHEN Xiao-hua，LI Shu-ping，HE Jin-xiang，QI Ning，ZHANG Zhu-xiang，WANG Ning，LIN Hui-qin 　　（Department of Radiology，First Hospital Affiliated to Lanzhou University，Lanzhou 730000，Gansu，China） 　　Abstract：Objective To investigate the hypofractionated three-dimensional conformal radiotherapy（3DCRT）efficacy and toxicity in treatment of elderly patients with non small cell lung cancer.Methods 32 cases of elderly patients with stage I non small cell lung cancer（NSCLC）were randomly divided into three-dimensional conformal radiotherapy group and conventional radiotherapy group.Among them，15 cases were divided into radiotherapy group，prescription dose DT 48～60 Gy，3～6 Gy/times，5 times/w；Conventional radiotherapy group 17 cases，prescription dose DT 66 Gy，2 Gy/times，5 times/w.Results Hypofractionated radiotherapy group and conventional radiotherapy group complete remission（CR）rate were 40.00%，17.70%，partial remission（PR）rate were 46.70%，23.50%，efficiency（CR+PR）were 86.70% and 41.20%（P0.05）；1，2，3 year survival rate of radiotherapy group were 80.00%and 53.30%.33.30%，conventional radiotherapy group were 47.10%，23.50%，17.60%.The incidence of radiation esophagitis and radiation pneumonitis was similar.Conclusion The effect of large fractionated three-dimensional conformal radiotherapy for elderly patients with stage I per