非小细胞肺癌放化疗不同联合模式疗效 生活质量评价与预后因素分析-肿瘤学专业论文.docxVIP

— — PAGE 3— 新疆医科大学医学硕士学位论文 Efficacy,the evaluation of quality of life and analysis of prognostic factors on non-small cell lung cancer accepted different treatment styles Postgraduate:Yang mei Supervisor:Prof.Zhang li Abstract Objective: To explore the efficacy of different treatment styles in order to evaluate the clinical effect and toxicity and to investigate the influence of quality of life of concurrent chemo-radiotherapy and sequential chemo-radiotherapy and chemotherapy for non-small cell lung cancer (NSCLC) . To research the influence of prognostic factors of NSCLC.Methods: 151 patients with NSCLC were divided into three groups: concurrent chemo-radiotherapy group (43 patients) and sequential chemo-radiotherapy group (49 patients) and chemotherapy only group (59 patients) . To evaluate the efficacy of different treatment styles,and patients were analysis by European Organization for Research and Treatment of Cancer’s quality of Life Questionnaire-Core (EORTC QLQ-C30) before therapy,after therapy (4th week) and after therapy 1 month. To analysis prognostic factors of NSCLC.Result: (1) The overall response rate in the three group was 81.4%,73.5% and 39%,respectively. The rate of the overall response in concurrent chemo-radiotherapy group and sequential chemo-radiotherapy group were higher than chemotherapy only group (P0.05); (2) the median survival time was 26 months, 12 months, 11 months,respectively,the median survival time in concurrent chemo- radiotherapy group was longer than the others (P0.05) ; 1-year survival rate was 60.8%, 47.1% and45.6%, respectively; 2-year survival rate was 58.2%,38.5% and 8.1%, respectively; 3-year survival rate was 32.7%,22.9%,0,respectively.The overall survival rate of concurrent chemo- radiotherapy group was higher than chemotherapy only group (P0.05),there were no difference in concurrent chemo-radiotherapy group and sequential chemo- radiotherapy group; (3) Hematologic toxicities of concurrent chemo-radiotherapy group and