非小细胞肺癌患者贫血的危险因素及其相关的生存分析-肿瘤学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要·················································································1 英文摘要·················································································4 研究论文 非小细胞肺癌患者贫血的危险因素及其相关的生存分析 前言·················································································7 材料与方法········································································8 结果···············································································10 附图···············································································16 附表···············································································24 讨论···············································································31 结论···············································································39 参考文献·········································································40 综述 EPO 治疗肿瘤相关性贫血的研究进展···································44 致谢·····················································································56 个人简历···············································································57 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 非小细胞肺癌患者贫血的危险因素及其相关的生存分析 摘 要 目的：恶性肿瘤的发病率近年持续升高，随着治疗手段的增多，患者 生存时间较前有所延长，但是出现肿瘤相关并发症的患者越来越多，肿瘤 相关性贫血是其中较为多见的并发症，肿瘤侵及血管导致出血、侵及骨髓 影响造血、放化疗治疗抑制骨髓功能、损伤消化道粘膜影响营养吸收等多 种因素均可导致贫血的发生。肿瘤相关性贫血会降低患者的生活质量，降 低患者放化疗治疗的疗效，甚至促进肿瘤的转移、缩短患者的生存时间。 但即便如此，临床医生及患者仍未对肿瘤相关性贫血产生足够的重视，贫 血的治疗率仍然较低。在各类恶性肿瘤中，贫血发生率排名的前三位的分 别是上消化道恶性肿瘤、乳腺癌和肺癌。肺癌在我国乃至世界上的发病率 及死亡率均位居榜首。在肺癌中，非小细胞肺癌(non-small cell lung cancer NSCLC)在各类病理类型中占据 80%以上，本研究通过调查 NSCLC 患者 临床病理资料、贫血相关的血液学检验结果、肺癌相关的治疗方法后，回 顾性分析 NSCLC 患者发生贫血的危险因素、贫血以及应用抗贫血治疗患 者的生存差异，使 NSCLC 患者的贫血受到其应有的重视，并为 NSCLC 患者贫血的规范化治疗寻求依据。 方法：本研究通过搜集 2008 年 1 月至 2014 年 12 月期间首次就诊于 河北医科大学第四医院经组织病理学或细胞学明确诊断为非小细胞肺癌 的患者，共计 848 例，病历采集的内容包括患者的一般临床病理情况、血 常规、肝功能等相关血液学检验指标、住院后具体的治疗手段，并通过电 话的方式进行随访，建立相应的资料数据库，统计学的分析采用 SPSS13.0 的统计软件进行，其中计数资料的描述采用频数和频率，通过 X2 检验分 析比较各个临床病理特征以及不同的治疗方法与贫血发生率的关系，贫血 发 生 相 关 的 危 险 因 素 采用 Logistic 回 归 分 析 法 进 行 探 讨 。 采 用 Kap