代谢综合征对女性生育功能的影响及相关机制研究妇产科学(生殖医学)专业论文.docx

汕头大学医学院硕士学位论文 汕头大学医学院硕士学位论文 PAGE PAGE IV Abstract Background and objectives: Metabolic syndrome identifies individuals at increased risk for central obesity, type 2 diabetes, dyslipidemia and Insulin resistance (Insulin Resistant, IR) as the pathophysiological basis, and it is a variety Pathological state of metabolic composition anomalies gathered, and it happens possible relevant with Insulin resistance. Central obesity and insulin resistance are thought to be the two major risk factors for the development of metabolic syndrome. Normal ovarian follicular experience a series of physiological processes of raise, selection, advantage and ovulation. Metabolic syndrome is characterized by chronic follicular raising more, choice and advantages thwarted, development stagnation and lack of ovulation. There is research showing that the developmental disorders of follicular is relevant with the influence of high insulin hematic disease to follicle granulosa cells cells. Insulin resistance and obesity will affect the quality of the oocytes, and there is no explicit theory basis. Most studies related to the metabolism factors limit in other organizations and cells, and rare reports research the metabolic factors of follicular liquid, ovarian granulosa cells and endometrium. If we can find the related molecular mechanism between the metabolic syndrome and normal female follicular liquid, ovarian granulosa cells and endometrium, it can a new effective guidance for assisted reproductive technology to improve the rates of embryos and clinical pregnancy of infertility patients with the metabolic syndrome. This study aims to discuss the relationship between MS and IVF-ET, and to further explore the expression of the IRS2, PPAR-γ mRNA in the Granular Cells from the patients with the Metabolic Syndrome（MS）and the normal women and investigate the invasive relation between infertilty and MS. Methods：Patients undergoing IVF (including intracytoplasmic sperm injection, ICSI) were stud