《木薯淀粉微球合成工艺条件的研究》-毕业论文（设计）.doc

PAGE 壹拾叁 广 西 大 学 毕业论文 课题 木薯淀粉微球合成 工艺条件的研究 学 院 化学化工学院 专 业 化学工程与工艺 班 级 2008级(2)班 学 号 0804100410 姓 名 指导教师 年 月 日 摘 要 淀粉微球是一种新型功能性高分子微球材料，具有可生物降解、无毒、生物相容性好等优点，作为药物载体在医药领域已经得到了广泛而实际的应用，在废水处理及重金属富集回收等领域也具有广阔的应用前景。其中淀粉微球粒径的大小对其应用有很大影响，淀粉微球合成工艺研究成为人们关注的热点。 本论文以木薯淀粉为原料，Span-80和Tween-80为乳化剂，液体石蜡为油相，N,N-亚甲基双丙烯酰胺(MBA)为交联剂，过硫酸铵为引发剂，采用反相乳液法制备淀粉微球。通过单因素实验讨论了淀粉浓度、油水比、交联剂浓度、乳化剂浓度和引发剂浓度对淀粉微球平均粒径的影响。得到制备木薯淀粉微球的最优工艺条件:淀粉浓度为10%，油水比为8:1，交联剂MBA浓度为0.8%，引发剂过硫酸铵浓度为1.2%，乳化剂浓度为14.4%（以上浓度变化均以总水量为25 ml（即25 g）为基准）。在此条件下制备的淀粉微球平均粒径10.2 μm，粒径主要分布在6~30 μm。得到的淀粉微球呈球形，表面粗糙多孔，作为药物载体具有广阔的应用前景。 关键词:木薯淀粉 淀粉微球 反相乳液 聚合 Study on the preparation of cassava starch microspheres Abstract Starch microspheres is a novel functional polymer microspheres, with the advantages of biodegradable, non-toxic, non-immunogenic, etc. It has been extensive and practical applications in the medical field as a carrier for targeted drug, and its application prospects will be very broad in the field of wastewater treatment and accumulation of heavy metals recovery. The particle size of starch microspheres has a great influence in its application. In this paper, the starch microspheres were prepared from cassava starch through reversed phase emulsion system, using Span-80 and Tween-80 as emulsifier, whiteruss as oil phase, N,N-methylene-bisacrylamide as crosslinker, Ammonium persulfate as initiator. Using the diameter of CCSM as response variable, cassava starch concentration, oil and water phase volume ratio, the amount of crosslinking agent, initiator dosage and the amount of emulsifier were study by single factor design experiment. The optimum polymerization conditions were decided by experiments as follows: cassava starch concentration of 10%, water and oil phase volume ratio of 8:1, the crosslinking agent MBA concentration of 0.8%, initiator over the ammonium sulfate concentration