健康青年人在急进高原后同海拔不同时相血压.doc

［通信作者］ 李素芝，电话：（0891）6858166，Email：pxl.1982@ 健康青年急进高原初期心脏功能变化特点初探 潘丽，李素芝 (400038 重庆 第三军医大学高原医学系) ［摘要］目的：了解健康青年人由平均海拔400米平原（Plain）初次进入平均海拔3680米高原(Highlands)（平均海拔3680米）后同海拔、不同时相（进入高原后1天、1周、1月）的心脏功能（Cardiac Function CF）的变化情况。方法：采用美国索诺声公司MMS型便携式心脏彩超仪，平卧位，分别测47例健康青年人在平原地区及进入高原地区后同海拔不同时相CF，重点考察射血分数（Left Ventricular Ejection Fraction LVEF）、短轴缩短率（Left Ventricular Minor Axis Decurtation LVMAD, △D%）、每搏量（Stroke Volume SV）、肺动脉压(Pulmonary Artery Pressure PAP)、心输出量(Cardiac Output CO)5项指标。对测得结果进行统计分析。结果：与平原相比较，进入高原1天的SV、 PAP、CO有显著性差异（P＜0.05）；进入高原1周的射血分数 LVEF、△D%、SV、PAP有显著性差异（P＜0.05）；进入高原1月时5项指标均有显著性差异（P＜0.05）；与进入高原1天相比，进入高原1周的LVEF、△D%、SV、CO有显著性差异（P＜0.05）；进入高原1月的PAP及CO有显著性差异（P＜0.05）；与进入高原1周相比较，进入高原1月的LVEF、△D%、CO有显著性差异（P＜0.05）。结论：健康青年的CF在平原时和进高原后同海拔不同时相间都有明显的变化，并且各项指标都有其各自的变化特点，总结这些变化规律可以通过对急进高原人群进行有针对性的健康教育而降低急性高原病（Acute High Altitude Sickness AHAS）的发病率。 ［关键词］健康青年；平原；高原；心功能 ［中图法分类号］：R541 Initial study of Cardiac function changes in healthy young adults following rapid travel to highlands Pan Li，Li Suzhi (High Altitude Military Medical Faculty, Third Military Medical University, Chongqing, 40038, China) ［Abstract］Objective To understand the cardiac function changes in healthy young adults occurring after initial transition from lower altitude localities to high altitude localities，at constant altitude after varied time intervals(1day/1week/1month after entry onto highlands),and grasp their basic patterns. Methods Use the Doppler echocardiography , the cardiac function of 47 healthy young adults was measured on plains, and at constant altitude after varied time intervals following arrival on highlands when they were lied low. Focus on Left Ventricular Ejection Fraction (LVEF）、Left Ventricular Minor Axis Decurtation ( LVMAD, △D%）、Stroke Volume( SV）、Pulmonary Artery Pressure (PAP) and Cardiac Output(CO).A statistical analysis was performed on the four result sets obtained. Results Comparing with plain, there are significant difference of the SV、PAP and CO 1day after arriving