胰岛素受体底物家族成员的结构跟组织特异性跟功能的关系_唐辰义新.pdfVIP

2016, 36(3) ht p:// J Clin Pathol R e s doi: 10.3978/j.issn.2095-6959.2016.03.016 View this article at: ht p:///10.3978/j.issn.2095-6959.2016.03.016 410011 (insulin)/1(insulin-like growth factor 1IGF-1) /IGF-1(insulin receptor IR) (insulin receptor substratesIRSs) IRSs (docking protein)Src2(SH2) IRSs IRS-1 IRS-6 6 IRS-1 2IRS-3IRS-4 56 IRSs 1-6 Src2 Tissue specii c functions of insulin receptor substrate family members based on their molecular structures TANG Chenyi, ZHOU Houde (Institute of Endocrinology and Metabolism, the Second Xiangya Hospital, Central South University, Changsha 410011, China) Abstract Insulin/Insulin-like growth factor 1 (IGF-1) signaling pathway plays important roles in cell dif erentiation, growth, survival and metabolism. Firstly, insulin/IGF-1 binds with insulin receptor to phosphorylate insulin receptor substrates (IRSs), which forms a tightly coupled trimer and then the phosphorylated IRSs activate a series of downstream Src homology 2 (SH2) containing proteins such as docking proteins, and then initiated a series of corresponding biological ef ects on target cells. h ere are 6 members in IRSs family from IRS-1 to IRS-6 among which the distribution is distinct from each other in various tissues. IRS-1 and IRS-2 distribute widely in dif erent tissues and IRS-3 expresses more in adipose tissue while IRS-4, IRS-5 and IRS-6 distribute very few in human tissues. Here we summarized the tissue specii c functions of insulin receptor substrate family members based on their molecular struct