大肠埃希菌和肺炎克雷伯菌ctx-m型esbls的分析.pdf

in The ofCTX·-MESBLsEscherichiacoli Study type Klebsiella and pneumoniae Abstract [Objective] The ofExtended an production spectrum to in mechanismofresistance antibiotic important 13-1actam isa of can enterobacteriaceae．ESBLs largefamilyp-lactamaseshydrolyze firsttofourth and penicillins，the generationcephalosporins monobactams．ESBLsare Klebsiella mainlyproducedby pneumoniae andEscherichia strainshavebeen in coli．ESBLs—producing widespread theworld．The ofESBL strainsdiffersindifferent genotype producing countriesorareasbecauseofthedifferentuseofantibacterialis agents．It showedthatTheCTX—M arethemost ESBLsin type widespreadmany the of orderto situationCTX-M country．In clarify typeenzymesspreaded inShenzhenarea．215 EscherichiacoliandKlebsiella ESBLs-producing isolatesfromShenzhen were for pneumoniae people、Shospitalanalysed antibioticresistance． theirCTX-Mand gene [Methods] 1 strainswereselectedfrom 5