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* * Overall, 77.9% of patients had a history of documented ischemic events1 Overall, 37.4% of patients had documented CAD at baseline:1 24.7% had previous MI 11.4% had angina with documented multivessel CAD 9.4% had a history of multivessel CABG 5.4% had a history of multivessel PCI Overall, 27.7% of patients had documented cerebrovascular disease at baseline:1 20.8% had a previous ischemic stroke 7.9% had a previous TIA Overall, 18.2% of patients had documented symptomatic PAD at baseline:1 11.4% had current intermittent claudication and an ABI value ≤0.85 10.5% had a history of intermittent claudication and prior intervention Reference 1. Bhatt DL, Fox K, Hacke W, et al. Am Heart J 2005; 150: 401. * In CHARISMA, major atherothrombotic risk factors were as follows:1 Type 1 or 2 diabetes currently under drug therapy Diabetic nephropathy ABI ?0.9 Asymptomatic carotid stenosis ?70% Presence of at least one carotid plaque evidenced by intima–media thickness In CHARISMA, minor atherothrombotic risk factors were as follows:1 SBP ?150 mmHg, despite therapy for at least 3 months Primary hypercholesterolemia Currently smoking ?15 cigarettes per day Male aged ?65 years or female aged ?70 years Reference 1. Bhatt DL, Topol EJ, et al. Am Heart J 2004; 148: 263–268. * Overall, 21.0% of patients had multiple risk factors (pre-event) at baseline1 Of those patients with inclusion criteria major risk factors at baseline:1 80.8% had type 1 or 2 diabetes 42.7% had diabetic nephropathy 12.5% had at least one carotid plaque 7.8% had asymptomatic carotid stenosis ≥70% 5.7% had ABI 0.9 Of those patients with inclusion criteria minor risk factors:1 61.6% had primary hypercholesterolemia 51.6% were males aged ≥65 years or females aged ≥70 years 47.2% had SBP ≥150 mmHg 16.6% were currently smoking 15 cigarettes per day Reference 1. Bhatt DL, Fox K, Hacke W, et al. Am Heart J 2005; 150: 401. * CHARISMAClopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Manag