T细胞亚群进展临床意义.pptVIP

Discovery of Suppressor T Cells In 1995, Sakaguchi et al made the seminal observation: The transfer of CD4+ T cells which had been depleted of the the minor subpopulation (10%) of cells to nu/nu recepients induced organ-specific autoimmune diseases in the majority of recipients. The minor subpopulation of cells are CD4+CD25+ T cells. Discovery of Suppressor T cells CD4+CD25+ Regulatory T cells A unique lineage of regulatory T cells capable of maintaining self tolerance in vivo * T CD8 CD4 CD4+ 25+ Th1 Tc2 Tc1 Th2 Th3 Tr1 Peripheral T lymphocyte 5-10% 30% Th4? 60% Thymus * Overview of phenotyp