pathgeniccocci病原性球菌.pptVIP

1. What are the main differences between Neisseria meningitides and Neisseria gonorrhoeae. Question: Pseudomonas aeruginosa (铜绿假单胞菌) P190 Shape, Stain Culture G－ bacili single terminal flagellum appears capsule in some bacterial strains grows readily and rapidly on many media produces several kinds of water-soluble pigments Biological properties Pseudomonas aeruginosa colonies on agar plates Pathogenicity immunity adhesins pilus non-pilus adhesin polysaccharide capsule endotoxin lipopolysaccharide (LPS) Pathogenic substances exotoxins exotoxin A ---mode of action similar to diphtheria toxin exotoxin S (exoenzyme S) ---inhibits phagocytosis ---acts in vitro in the same way as the toxins of Vibrio cholerae elastase (弹性蛋白酶) ---Las-A(丝氨酸蛋白酶) ＆ Las-B(锌金属蛋白酶) phosphoesterase C (磷脂酶 C) pyocyanin (绿脓菌素) Cytolysin: e.g. leukocidin Clinical diseases Opportunistic pathogen —infections following burn —hospital-acquired infections Pulmonary infections Primary skin infections Urinary infections Primary skin infections of Pseudomonas aeruginosa 1. Discuss the pathogenic features of Pseudomonas aeruginosa. Question: Group A Streptococci (S. pyogenes) Pathogenic substances Protein G: similar to Protein A adhesins -lipoteichoic acid (LTA) -fibronectin binding protein (FBP, protein F) (纤丝蛋白结合蛋白, F 蛋白) -protein M Bacterial structure Streptolysin (SL, 链球菌溶素) Streptococcal pyrogenic exotoxin (SPE, 链球菌致热外毒素) Hyaluronidase (透明质酸酶) Streptokinase (SK, 链激酶) Streptodornase (SD, 链道酶) Toxins enzymes Streptolysin S (SLS, 链球菌溶素S) -low MW glycopeptide -oxygen-stable -causes ?-hemolysis on Blood Agar plate -non-antigenic Streptolysin O (SLO, 链球菌溶素O) -protein w/ SH group -oxygen-labile -destroys many kinds of cells -anti-SLO test (ASO test) helpful for diagnosis Streptolysin -coded by lysogenic bacteriophage -proteins including serotype A, B, C -causes scarlet fever (猩红热) -one kind of