LFABP TP基因多态性与高脂血症和非酒精性脂肪肝的相关性.docxVIP

其总的胆固醇分别为5．1±0．9、4．6±0．8(P=0．00)：其低密度脂蛋白 其总的胆固醇分别为5．1±0．9、4．6±0．8(P=0．00)：其低密度脂蛋白 胆固醇的值分别为3．02±0．71、2．64±0．68(P-0．00)。在女性中也未 发现这种相关性。logistic回归分析显示，拥有MTP 128T等位基因的 人与野生型相比还有更小的罹患高脂血症的机率(0R=0．56，95％ CI：0．36．0．88 P=0．01)。但是未发现这两种基因突变与非酒精性脂肪肝 发病相关。 结论：1、L-FABP T94A与MTP 1128T基因突变频率存在着种族差 异，L—FABP 94A与MTP 128T在中国人群中的突变频率比西方人低。2、 在男性中L．FABP T94A与MTP 1128T突变可影响某些血脂水平及相关 的指标。3、MTP的1128T突变与高脂血症相关， 128T等位基因的频 率在高脂血症中比对照组低，拥有MTP 128T的人罹患高脂血症的机率 比拥有1281等位基因的人小。4、L—FABP T94A与MTP 1128T突变与 非酒精性脂肪肝发病无关。 关键词：L-FABP，MTP，多态性，高脂血症，非酒精性脂肪肝 Ⅱ ABSTRACTBackground：Liver ABSTRACT Background：Liver is the important organ for synthesis and utilization for lipids．The disorder in entering or excreting of lipids from liver can cause lipids deposit in periphery or in the liver which may result in related diseases such as hyperlipidemia or non—alcoholic fatty liver．Liver fatty acid binding protein(L-FABP)and microsomal triglyceride transfer protein(MTP)are two important transporters for lipids entering into the liver or excreting from the liver respectively, L—FABP transfers the long chain fatty acid into the liver for lipid metabolism while MTP play an important part in keeping very low density lipoprotein excreting from the liver normally．Recently,It was indicated that L—FABP T94A and MTP 1128T polymorphisms may jnfluence the function of L-FABP and MTP,thus may have influence on lipid metabolism and related diseases． Aims：0ur aim iS to investigate the possible roles of L．FABP T94A and MTP 1128T polymorphisms in modulating susceptibility of hyperlipidemia and non-alcoholic fatty liver． Methods：We analyzed 41 5 subjects involved hyperlipidemic subjects and the age sex matched controls and 458 subjects involved patients with non-alcoholic fatty liver and the age sex matched controls． Case history、anthropometric indexes，lipids profiles，blood pressure， fasting blood glucose、liver function were collected．L-FABP T94A and MTP 1128T genotype were obtained using PCR．RFLP method．ANOVA， chi square，lo