超敏反应-215-英五班.ppt

Mechanism of type II hypersensitivity （1）Ag cell surface Ag → Ab（IgG） （2）specific Ab, complement and effector cell ADCC、CDC、phagocytosis 2. Common diseases caused by type II hypersensitivity （1）transfusion reactions Blood type Ag Ab/serum A A anti-B B B anti-A AB A、B none O H anti-A、anti-B （2）Hemolytic disease of the newborn induced by Rhesus incompatibility （3）Autoimmune hemolytic anemia infection: changed epitope drug: hapten （4）Graves disease (special type) Thyroid epithelial cell TSH-R TSH T3、T4 Anti-TSH-R Ab III. Type III hypersensitivity （soluble immune complex） Mechanism of type III hypersensitivity large immune complexes-----phagocytosis small immune complexes-----kidney filtration medieum immune complexes-----exist for a long time, deposit in small vessels 2. Common diseases caused by type III hypersensitivity （1）local immune complex-mediated diseases 1903 Arthus Arthus reaction, arthus-like reaction Inhaled antigen induced type III hypersensitivity Diseases antigen hay dust farmers lung fur protein furriers lung pigeon droppings pigeon-fanciers disease Penicillium casei spores cheese washers disease Hidden mold spores maple bark strippers disease （2）Systemic immune complex-mediated diseases Serum sickness Poststreptococcal glomerulonephritis Rheumatoid arthritis Systemic lupus erythematosus Serum sickness IV. Type IV hypersensitivity （cell mediated, delayed type） Mechanism of type IV hypersensitivity Ag → effector cell Inflammation and cytotoxicity Th1 Tc 2. Common diseases caused by type IV hypersensitivity （1）Infective hypersensitivity Leprosy Tuberculosis Abul K. abbas et al. Cellular and Molecular Immunology, 7th edition, Elsevier Saunders Contact dermatitis ca