十二指肠空肠旁路术对2型糖尿病肾病大鼠到肾功能的影响的研究分析-外科学(普通外科)专业毕业论文.docx

原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独 原创性声明 本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独 立进行研究所取得的成果。除文中已经注明引用的内容外，本论文不 包含任何其他个人或集体已经发表或撰写过的科研成果。对本文的研 究做出重要贡献的个人和集体，均已在文中以明确方式标明。本声明 的法律责任由本人承担。 论文作者签名： ——■少——V—一落 日 期： 关于学位论文使用授权的声明 本人完全了解山东大学有关保留、使用学位论文的规定，同意学 校保留或向国家有关部门或机构送交论文的复印件和电子版，允许论 文被查阅和借阅；本人授权山东大学可以将本学位论文的全部或部分 内容编入有关数据库进行检索，可以采用影印、缩印或其他复制手段 保存论文和汇编本学位论文。 (保密论文在解密后应遵守此规定) 论文作者签名：兽缸导师签名：曲细期：地乙 目录 目录 中文摘要······························1 英文摘要·····················-········7 符号说明······························12 第一部分2型糖尿病肾病大鼠模型的建立 前言·······························14日IJ舌 。14 材料和方法 17 结果······························21 讨{念·······························24 结论······························29 附表··················-···········30 附图······························34 参考文献····························39 第二部分十二指肠空肠旁路术对2型糖尿病。肾病大鼠肾功能的影响 前言······························44日U舌 。44 材料和方法 46 结果······························52 讨论······························55 结论······························59 附表······························60 附图······························62 参考文献····························68 致谢································74 攻读学位期间发表的学术论文···························75 英文文章1·····························76 英文文章2·····························96 CATALOGUEAbstract CATALOGUE Abstract in Chinese········································l Abstract in English 7 Symbolic description 12 Part I The establishment of rat models of type 2 diabetic nephropathy Introduction 14 Materials and methods 17 Results······························2l Discussion 24 Conclusion 29 Tables 30 Figures 34 References 39 Part II The effect of duodenal-jejunal bypass on Renal function in a diabetic nephropathy rat model Introduction 44 Materials and methods 46 Results 52 Discussion 55 Conclusion 59 Tables 60 Figures 62 References 68 Acknowledgement 74 List ofpublished papers。 75 English paper l 76 English paper 2 96 山东大学博士学位论文中文摘要 山东大学博士学位论文 中文摘要 第一部分2型糖尿病肾病大鼠模型的建立 背景 在世界范围内，糖尿病发病率呈逐渐上升趋势。其中90％以上是2型糖尿病。 糖尿病肾病(Diabetes