酒精滥用与成瘾中枢神经递质研究进展.pdfVIP

( ) ( ) 中国药物依赖性杂志 Ch in J D rug D ep end 2007, 16 1 : 5 - 11 ·5 · [综述 ] 酒精滥用与成瘾中枢神经递质的研究进展 1 1 2 陈　锋 　A ndrew J L aw rence 　梁建辉 1 (M elbourne大学 Howard F lorey研究所 , V ictoria, 30 10) 2 (北京大学中国药物依赖性研究所 ,北京 , 100083) 　　酒精滥用及其成瘾是一种失控且紊乱的饮酒行 现戒断症状以及各种并发症外 ,还突出表现为强迫 ( ) 为 , 被定义为一种病理状态行为综合征 。酒精成瘾 性觅酒行为 ,对酒的强烈渴求 craving 和对酒的反 患者除了机体出现对酒精产生耐受 , 中断饮酒后出 复滥用 , 并且这些行为特征即使在断酒数年后也可 [ 12 ] R ao VL , Dogan A , Todd KG, et al. A n tisen se knockdown of the glial glutam ate tran sporter GL T - 1, bu t not the neuronal glutam ate tran sporter EAAC1, exacerbate s tran sient focal cerebral ischem ia - induced neu ronal dam age in rat b rain [ J ]. J N eu ro sci, 200 1, 2 1: 1876 - 1883 [ 13 ] Enrico P, M ura MA , E spo sito G, et al. Effect of naloxone on morp h ine - induced change s in striatal dop am ine m etabolism and glutam ate, a scorb ic acid and uric acid relea se in freely moving rats [ J ]. B rain R e s, 1998, 797: 94 - 102 [ 14 ] N akagawa T, Ozawa T, Sh ige K, et al. Inh ib ition of morp h ine tolerance and dep endence by M S - 153, a glutam ate tran sporter activator [ J ]. Eu r J Pharm acol, 200 1, 4 19: 39 - 45 [ 15 ] N akagawa T, Fuj io M