基于prf法的磁共振测温技术研究-机械电子工程专业论文.docxVIP

万方数据 Classified Index：R318.6 U.D.C.: 621 Dissertation for the Master Degree in Engineering STUDY OF MAGNETIC RESONANCE THERMOMETRY BASED ON PROTON RESONANCE FREQUENCY Candidate： Zheng Jialei Supervisor： Associate Prof. Liu Shoubin Academic Degree Applied for： Master Degree in Engineering Speciality： Mechatronics Engineering Affiliation： Shenzhen Graduate School Date of Defence： December, 2013 Degree-Conferring-Institution： Harbin Institute of Technology 哈尔滨工业大学工学硕士学位论文 摘 要 磁共振测温技术在无创测温领域特别是肿瘤热消融手术中已得到广泛应用。 通过质子共振频率等方法完成的磁共振测温是磁共振测温的技术前沿。质子共振 频率法是基于质子的化学位移现象实现的，化学位移是指处于磁共振环境下的质 子共振频率会因为电子云的存在而与温度产生一定关系。质子共振频率法因为运 动及磁场漂移等影响很难准确测量人体组织内的油脂分子和水分子的共振频率 差，本文通过建立新的温度模型并运用数学算法来获取传统磁共振信号中的频差 信息，同时选定组织中对温度不敏感的质子作为参考物，实现磁共振的测温功 能。 建立等间隔采样的温度模型，采用扩充的 PRONY 参数估计算法对模型中与 温度相关的共振频率变量进行求解，通过合理的近似来简化运算使本来的非线性 问题转化为线性问题以提高计算速度，实现了从磁共振采集信号中提取与温度有 关的频差信息这一目的，并通过标定实验建立温度同模型中油脂分子和水分子共 振频率差的线性关系。根据温度模型的需要，设计新的多回波梯度回波测温序 列，对其中重要参数进行优化，并通过软件编程实现。运用改进的拥有自适应特 性的非局部平均滤波 法 对新序列采集得到 的多幅图像 进 行 降 噪 处 理 ， 利用 MATLAB 技术实现本文算法，对降噪后图像进行数据处理，最终重建出温度图 像。 关键词：测温；质子共振频率；扩充 PRONY 算法；降噪 I -  Abstract MR thermometry temperature fields, especially in the non-invasive thermal ablation of tumor surgery has been widely used. By proton resonance frequency magnetic resonance methods in temperature measurement is complete MRI thermometry cutting edge of technology. Proton resonance frequency method is based on the achieved phenomenon of proton chemical shifts, in magnetic resonance chemical shift is the proton resonance frequency environment because of the presence of the electron cloud and have a certain relationship with temperature. Because of the movement and magnetic field drift effect proton resonance frequency method is difficult to achieve accurate measurement of the different resonance frequency between water and oil, through the establishment of a new temperature model and use mathematical algorithms this paper obtain magnetic resonance signal frequency difference information, while the selected organizati