CD8+T细胞在多发性硬化中的致病性作用.PDFVIP

18 3 Vol. 18, No. 3 2006 6 Chinese Bulletin of Life Sciences Jun., 2006 1004-0374(2006)03-0244-03 + CD8 T / 200025 T CD4+ T CD8+ T CD8+ T MS CD8+ T MS CD8+ T MS CD8+ T CD8+ T CD4+ T R593.2 R329.25 A + The pathogenic roles of CD8 T cells in multiple sclerosis MEI Yun-Hua, XU Ling-Yun* (Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiaotong University School of Medicine) Abstract: Multiple sclerosis (MS) is a T cell mediated autoimmune disease. Previous researches focus on the roles of CD4+ T cells, including the pathogenic and immune-regulatory roles. However, more and more evidences show that CD8+ + T cells act as an important factor in the development of MS. CD8 T cells were founded in the lesions of MS, and myelin antigen specific CD8+ T clones were isolated from MS patients. The autoreactive CD8+ T cells can damage target cells directly or amplify local inflammation through secreting cytokines and chemokines. + Illustrating the roles of CD8 T cells in MS will help us better understand the mechanisms of MS and find new prevention and therapeutic methods. Key wards: CD8+ + T cells; CD4 T cells; multiple sclerosis; experimental autoimmune encephalomyelitis (multiple sclerosis, MS)T (experimental au- toimmune e