真核生物的基因表达调控.pptVIP

* Steroid hormones are too hydrophobic to readily dissolve in blood. Therefore, they travel on specific carrier proteins from point of release to their target tissues. In the target tissue, the hormone passes through the plasma membrane by simple diffusion and binds to its specific receptor protein in the cytoplasm (as shown here) or in the nucleus (see retinoic acid receptor [RAR] below). * * Near the initiation site A little far away SP1 stimulates transcription in presence of TAFII110 GC boxes bound by DNA binding protein SP1 SP1 recruits TFIID by binding TAFII110 Partially reconstitut