加州大学伯克利分校有机化学课件.pptVIP

? University of California ? Univesity of California Chapter 20: Carboxylic Acid Derivatives What is the relative reactivity of these carboxylic acid derivatives? Origins of Reactivity Trends Comparing Reactivity A. Alkanoyl Halides B. Anhydrides C. Esters D. Amides E. Alkanenitriles A. Alkanoyl Halides B. Anhydrides C. Esters D. Amides E. Alkanenitriles: RCN Structure Nitriles are Acidic and Basic Mass Spectrometry 2. Reduction to an amine Mechanism: 3. Reduction to an aldehyde Mechanism goes by single hydride addition to hemiaminal stage, then hydrolysis. Acidic, like carboxylic a