肺癌的基因西组学和蛋白组学研究.pptVIP

选择基因还是临床标记?Are Gene Signatures Redundant? 肺腺癌中基因表达为基础的生存预测K. Shedden et al. Nat Med 14:822, 2008 从基因到蛋白 蛋白组学与化疗敏感性相关 从基因到蛋白 基因组学还是蛋白组学? Global gene-expression profiling using microarray technologies Has helped improve our understanding of the histological heterogeneity of NSCLC. Has identified potential biomarkers gene signatures for classifying patients with significantly different survival outcomes. However, the performance general applicability of published classifiers has not been easy to establish because of small numbers of subjects examined inclusion of heterogeneous tumor types.