铅接触工人的综合心电图分析-麻醉学文献进展分享平台.PDF

文献进展摘要及翻译 贵州医科大学麻醉学系研究生（心电生理及记忆课题组） 文献名：（中文） 铅接触工人的综合心电图分析：一项心律失常 风险评估研究 （英文）Comprehensive Electrocardiographic Analysis of Lead Exposed Workers: An Arrhythmic Risk Assessment Study 译 者：文春雷 原文摘要： ABSTRACT Background: To evaluate electrocardiographic parameters which ar e related with atrial and ventricular arrhythmias measured from 12-l ead surface electrocardiogram (ECG) in workers occupationally expo sed to lead. Methods: Sixty lead-exposed workers and 60 healthy controls were e nrolled. Twelve-lead surface ECG was recorded and measurements of P wave durations (Pmax, Pmin) and P wave dispersion (PWD), QT durations and dispersion (QTd), corrected QT ( QTc), Tp-e interval, and Tp-e/QT ratio were analyzed. Results: The lead-exposed and control groups were similar withresp ect to baseline demographic, laboratory, and transthoracic echocardi ographic indices. PWD (26.3 9.7 vs 22.0 9.0 ms, P = 0.014), Pmin ( 89.9 13.8 vs 79.2 10.1 ms, P 0.001), and Pmax (116.2 15.0 vs 1 01.2 14.2 ms, P 0.001), QT maximum (377.0 27.6 vs 364.9 28. 5 ms,P = 0.02), QTd (38.4 16.5 vs 30.5 12.4 ms, P = 0.004), Tp-e in terval (78.9 16.5 vs 70.3 14.5 ms, P = 0.003), and Tp-e/QT ratio (0.2 2 0.04 vs 0.20 0.04, P = 0.013) were significantly higher in lead-ex posed workers. QT minimum and QTc values did not differ significant ly. QT maximum, QTd, and Tp-e/QT ratio were correlated with urine l ead level and Tp-e interval was correlated with both blood and urine lead levels. Conclusions: Lead-exposed workers have a higher risk for atrial and ventricular arrhythmias even without overt cardiac diseases compar ed with healthy subjects. These workers should be followed closely for adverse cardiovascular outcomes especially arrh ythmias. 摘要翻译： 背景：探讨铅接触工人的与房性和室性心律失常相关的心 电图参数。方法：60 例铅接触工人和 60 例健康对照组。记录试验 者十二心电图和测量 P 波间期（Pmax、Pmin）、P 波离散度（PWD）， QT 间期及离散度（QTd）、校正的QT