影响肠道菌群的因素.ppt

影响肠道菌群的因素 北美医学教育基金会 丁文京博士 肠道微生态和谐 Gareth C. Parkes, et al., Gastrointestinal Microbiota in Irritable Bowel Syndrome: Their Role in Its Pathogenesis and Treatment. Am J Gastroenterol 2008;103:1557–1567. 菌群紊乱 菌群紊乱 比例失调：主要是指肠道内的原籍常住菌（优势菌）大部分被抑制，而少数菌种过度繁殖，两者比例失衡。 细菌易位 横向易位是指肠道的正常菌群由原定位向周围转移 纵向易位是指正常菌群从原定位向肠黏膜深处转移。 导致菌群紊乱的因素 June L. Round and Sarkis K. Mazmanian. The gut microbiota shapes intestinal immune responses during health and disease. NATURE REVIEWS | IMMUNOLOGY, VOLUME 9 | MAY 2009 | 313-324. 影响肠道菌群的因素 Nathalie M. Delzenne Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31. 影响肠道菌群的因素 影响肠道菌群的因素 抗菌素影响肠道菌群 一次抗菌素治疗就可以长期改变肠道菌群 高脂饮食破坏肠粘膜 Patrice D Cani and Nathalie M Delzenne, Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Current Opinion in Pharmacology 2009, 9:737–743. 精神活动影响肠道菌群 Jason A. Hawrelak Stephen P. Myers, The Causes of Intestinal Dysbiosis: A Review. Altern Med Rev 2004;9(2):180-197. exposure to psychological stress results in a significant reduction in the production of mucin and a decreased presence of acidic mucopolysaccharides on the mucosal surface. 谢谢 联系方式P: 电话：010/8208 2279 传真：010/6236 3545 手机：135 0138 5080 手机：001-510/396-6618 (美国） QQ: 834983669 邮箱：abs94555@