有关不孕不育研究与管理英国指南 Investigating and treating subfertility.pptVIP

Anovulation不排卵症 Treatment OR (95% CI) Clomiphene vs no treatment 3.41 (1.23 to 9.48) Hughes et al. 2003, Cochrane FSH vs HMG 0.89 (0.53 to 1.49) Nugent et al. 2003, Cochrane GnRH agonist in PCOS 1.50 (0.72 to 3.12) Hughes et al. 2003, Cochrane 克罗米芬vs不予处置 促卵泡激素vs促性腺激素 促性腺激素释放激素激动剂在多囊卵巢综合征中应用 Clomiphene v Letrozole克罗米芬v来曲唑 Clomiphene (n=376) Letrozole (n=374) Significance Ovulation rates排卵率 48.3% 61.7% P=0.001 Live birth rates活产率 19.1% 27.5% P=0.007 Pregnancy loss流产率 29.1% 31.8% NS Twins双胞胎 7.4% 3.4% NS Congenital anomalies先天异常 1 4 P=0.65 Legro et al NEJM 2014 rFSH v u