Mina53和Mel-18在大肠癌组织中的表达及意义.doc

Mina53和Mel-18在大肠癌组织中的表达及意义 田永，邹艳芳，徐峰 单位：郑州大学第一附属医院 郑州 450052 摘要 目的：探讨大肠癌组织中Mina53与Mel-18蛋白的表达及其临床意义。 方法：采用免疫组织化学法分别检测60例不同病理分期的大肠癌及相应癌旁60例正常大肠粘膜组织中Mina53与Mel-18蛋白的表达。 结果：Mina53蛋白在大肠癌组织和正常大肠粘膜组织的阳性表达率分别为60.0%和0%，Mel-18蛋白的阳性表达率分别为31.7%和61.7%，2组之间差异均有统计学意义（χ2分别为51.429, 10.848,均P0. 05）。Mina53蛋白在大肠癌组织的表达与患者的性别、年龄无关（P0.05），而与肿瘤的浸润深度、淋巴结转移及分化程度有关（P0.05）。Mel-18蛋白的表达与患者的性别、年龄无关（P0.05），而与肿瘤的浸润深度、淋巴结转移及分化程度有关（P0.05）。Mina53与Mel-18蛋白在大肠癌组织中的表达呈负相关（r=-0.557，P 0.05）,并与肿瘤的浸润深度、淋巴结转移及组织的分化程度均相关（均P0.05）。 结论： Mina53与Mel-18的异常表达可能在大肠癌的进展中起重要作用。 关键词：大肠癌; Mina53; Mel-18; 免疫组织化学 中图分类号：735.3 Expression and Significance of Mina53 and Mel-18 in colorectal carcinoma Tian Yong,Zou Yanfang, Xu Feng the First Affiliated Hospital of Zhengzhou University； Zhengzhou，450052, China； Abstract AIM: To investigate the expression of Mina53 and Mel-18 proteins in colorectal carcinoma and to analyze their clinicopathological significance. 通信作者：徐峰 HYPERLINK mailto:xufengmd@ xufengmd@ METHODS: The expression of Mina53 and Mel-18 proteins was detected by immunohistochemistry in 60 colorectal carcinoma specimens and 60 normal colorectal mucosa specimens in different pathological stages. RESULTS: The positive rates of Mina53 and Mel-18 protein expression differed significantly between colorectal carcinoma and normal colorectal mucosa (Mina53: 60.0% vs 0%, Mel-18: 31.7% vs 61.7%, both P 0.05). The expression of Mina53 and Mel-18 proteins was found to be associated with tumor infiltration depth, lymph node metastasis and tumor differentiation in colorectal carcinoma (all P 0.05). A negative correlation was noted between the expression of Mina53 and that of Mel-18 in colorectal carcinoma(r =-0.557, CONCLUSION: The imbalance of Mina53 and Mel-18 expression may play an im-portant role in development of colorectal carcinoma. Key Words: Colorectal carcinoma; Mina53; Mel-18; Immunohistochemistry 作者 田永，男，出生于1987年9月，在读硕士，研究方向：消化道肿瘤，E-mail： HYPERLINK mailto:tianyong_1987@163.com tianyong_1987@163.com；