关键词毛囊;细胞色素C;毛囊发育差异中图分类号R3.docVIP

新生小鼠不同部位皮肤毛囊早期发育差异的比较? ?项目来源：内蒙古医科大学青年创新基金（nybq2010cq）；内蒙古计划科技项目（kjt13sf10） 作者简介：贾宇臣（1978-），女，讲师，内蒙古人，硕士，研究方向：分子生物学。Email: springxy2003@ *通讯作者：王利（1981-），男，讲师，内蒙古人，硕士。通讯地址：内蒙古呼和浩特市新华大街5号内蒙古医学院分子生物学研究中心 邮编：010059 Tel:0471-6637612，E-mail：wangliwork@163.com 贾宇臣，陈琦，李少伟，王利* (1内蒙古医学院分子生物学研究中心 内蒙古 呼和浩特 010059，中国 ) 摘要 目的：本研究旨在准确的构建出生后小鼠不同部位毛囊早期发育生长模型，研究小鼠不同部位皮肤毛囊发育的差异。方法：对新生1~9天的昆明白系小鼠背部、尾部和触须部皮肤取材，进行HE染色，用二步法免疫组织化学对组织进行细胞色素C进行表达分布检测。结果：新生小鼠不同部位皮肤毛囊发育差异很大，这种差异不仅体现在形态差异上，而发育时间的差异也十分明显。小鼠出生后背部皮肤和尾部皮肤的毛囊发育都经过了一个稳定抑制期，过了稳定期才开始快速生长，相比较尾部发育略迟于背部。触须部毛囊发育特征和背部尾部差异很大，一出生便可看到较成熟的触毛，没有经过稳定期便开始发育。结论：不同皮肤的毛囊发育存在一定差异，这种差异可能和小鼠对被毛的发育需求有很大关系。 关键词：毛囊；细胞色素C；毛囊发育差异 中图分类号：R3 Comparison of Early Developmental Differences of Hair Follicle in Different Skin of Neonatal Mouse JIA Yu-chen,LI Shao-wei,CHEN Qi, WANG Li* (1Hohhot Vocational College;2 Inner Mongolia University;3 Research Center of Molecular Biology, Inner Mongolia Medical University, Hohhot 010059,China) Abstruct Objective The study is to build the hair follicles of early growth and development model of postnatal mice in the different skin. Then study the difference of the of Kunming mice different parts of the skin hair follicle. Method The morphology of different skin hair follicles of mice（from postnatal 1day to 9 day） were observed by HE stain and detected cytochrome C by immunohistochemical staining(IHC).Result The different parts of the skin hair follicle of postnatal mice were differences not only in the morphology but also in developmental period. Hair follicle growth in the back and tail skin have a stable period. After the stable period began rapid growth. The tail development slightly slower than the back. The hair follicles of tentacle are very special, without stable period began development. Conclusion Differences existed in hair follicle of different skin, which may be related with mouse developmental needs for coat. Keywords: hair follicle; cytochrome C; hair follicle development difference 哺乳动物毛发是皮肤毛囊发育生长的衍生物。毛囊是皮肤重要的附