酮前列腺素F1α水平影响-食品科学.PDF

※营养卫生 食品科学 2011, Vol. 32, No. 17 317 B2 6- F1 α 1 2, 江新凤 ，邵宛芳 * (1.江西省蚕桑茶叶研究所，江西 南昌 330202 ；2.云南农业大学龙润普洱茶学院，云南 昆明 650201) 采用高脂饲料饲喂法建立高脂血症大鼠模型，同时以 0.5 、1.0、2.0g/(kg ·d) 3 种普洱茶的剂量饲喂昆明 种 SPF 级雌性大鼠 35d 后，检测大鼠血液总胆固醇(TC) 、甘油三酯(TG) 、高密度脂蛋白胆固醇(HDL-C) 、低密度 脂蛋白胆固醇(LDL-C) 的含量，采用ELISA 法定量测定大鼠血浆血栓素 B2 (thromboxaneB2 ，TXB2) 、6- 酮前列腺素 F 1 α(6-keto-PGF 1 α) 的含量。结果表明，普洱茶能明显降低模型大鼠血液TG 、TC 、LDL-C 、TXB2 含量，提高 HDL-C 、6-keto-PGF 1 α含量。 普洱茶；高脂血症；血栓素 B 2 ；6- 酮前列腺素 F 1 α Effect of Pu-erh Tea on Blood Lipid and Plasma TXB2 and 6-Keto-PGF1 α Levels in Hyperlipidemic Mice 1 2, JIANG Xin-feng ，SHAO Wan-fang * (1. Jiangxi Sericulture and Tea Research Institute, Nanchang 330202, China； 2. College of Longrun Pu-erh Tea,Yunnan Agricultural University, Kunming 650201,China) 　　 Abstract ：In order to establish a hyperlipidemic mouse model by feeding high-fat diet, SD mice fed Pu-erh tea at the dosages of 0.5, 1.0 g/(kg ·d) and 2.0 g/(kg ·d) for 35 consecutive days. The total cholesterol (TCHO), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in the blood of SD mice were determined. Meanwhile, plasma thromboxane-B2 (TXB2) and 6-keto-prostaglandin F1 α (6-keto-PGF1 α) were also analyzed by ELISA. The results showed that the levels of TCHO, TC, LDL-C and TXB2 in SD mouse blood exhibited a significant reduction in treatment groups while HDL-C and 6-keto-PGF1 α revealed a significant increase (P ＜0.05; P ＜0.01) when compared with the control group. Key words ：Pu-erh tea ；hype