脑肿瘤对大脑皮层运动区BOLD-fMRI信号的影响.docVIP

[基金项目]国家临床重点专科建设项目经费资助（财社[2011]170号） [通信作者]石全红，E-mail:shqh69@ 该雅虎中国的邮箱早已停用。 脑肿瘤对大脑皮层运动区BOLD-fMRI信号的影响 高 超，詹 傲，谢延风，石全红#（400016重庆，重庆医科大学附属第一医院神经外科） [摘要] 目的 采用血氧依赖水平功能磁共振成像（BOLD-fMRI）技术，探讨不同类型、性质、起源的脑肿瘤对大脑皮层运动区BOLD-fMRI信号激活范围、强度的影响。 方法 回顾性研究临近或累及大脑皮层运动区的48例脑肿瘤患者（恶性27例，良性21例）与10例非肿瘤患者，获得功能区BOLD激活图像，分析大脑皮层运动功能区BOLD-fMRI信号范围、强度与脑肿瘤间的关系。 结果 恶性脑肿瘤组信号范围及强度（范围：M Ⅰ：51.07±20.50，SM Ⅰ:29.89±16.27；强度：M Ⅰ：29.56±21.42，SM Ⅰ:23.64±10.31），良性脑肿瘤组信号范围及强度（范围：M Ⅰ：110.20±50.68，SM Ⅰ:77.89±18.55；强度：M Ⅰ：46.65±13.21，SM Ⅰ:38.21±13.25），非肿瘤组信号范围及强度（范围：M Ⅰ：183.45±43.95，SM Ⅰ:180.46±30.28；强度：M Ⅰ：65.13±16.55，SM Ⅰ:65.64±11.87）。3组间信号范围及强度差异明显（P＜0.05）。脑功能区成像范围与强度呈正相关（M Ⅰ：R2= 0.56，P0.05；SM Ⅰ: R2= 0.41，P0.05）。结论 BOLD-fMRI能无创、快速地对皮层功能区进行定位，对术前脑肿瘤良恶性的诊断起到一定参考作用，具有较高的临床价值。 [关键词]脑肿瘤；皮层运动区；BOLD-fMRI The influence of the BOLD-fMRI signal with brain tumors in the brain cortex motor area Gao Chao, Zhan Ao, Xie Yanfeng, Shi Quanhong（Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, NO.1 Youyi Rode,Chongqing 400016,China） [Abstract] Objective To discuss different types, nature, origin of brain tumors with the influence of the blood oxygen level functional magnetic resonance imaging (BOLD-fMRI) signal in the cerebral cortex motor area, including the strength and the scope. Methods Retrospective study of 48 patients with neighboring or cumulative movement cerebral cortex brain tumors (malignant 27 cases, 21 cases of benign) and 10 cases without brain tumors. Obtain the function BOLD activation images of motor cortex, analyzing the motion function of cerebral cortex BOLD fMRI signal with strength and scope and the relationship between different brain tumors. Results Signal range and intensity of malignant brain tumor group (range: M Ⅰ: 51.07±20.50, SM Ⅰ:29.89±16.27; strength: M Ⅰ:29.56±21.42, SM Ⅰ:23.64±10.31), the signal range and intensity of benign brain tumor group (range: M Ⅰ:110.20±50.68, SM Ⅰ:77.89 ±18.55; strength: M Ⅰ:46.65±13.21, SM Ⅰ:38.21±13.25), the signal ran