院士讲学周课件-银屑病免疫治疗.pptVIP

* Mukden Medical School (1891) Manchuria Medical University (1911) China Medical University (1931) in Psoriasis Immunopathogenesis Biologic Therapeutics Psoriasis is a T cell-mediated disease (a historical perspective) Previously, hyperproliferation and abnormal differentiation of KCs were assumed to be the primary defects. Prior therapeutics including retinoids, PUVA, UVB, and MTX, all of which have side effects. Later, it was found that mononuclear cell infiltration appears before epidermal changes. Studies with mAbs showed accumulations of CD4+ and CD8+ T cells. Accordingly it was sugges