肿瘤抗血管靶向治疗JG.pptVIP

* * * Jain. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7:987–9. Carmeliet, et al. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011;10:417–27. * * Avastin has demonstrated to increase survival (either PFS or OS) in 6 different tumor types including Ovarian cancer, where we reported two positive phase III studies in 2010 (GOG 218 and ICON-7). Ovarian cancer has been filed in the EU and the US filing is planned for Q4’2011. Last year we also reported that tr