一项DCS治疗难治性癫痫的临床对照研究.pdfVIP

Fregni et al. 1 A controlled clinical trial of direct current stimulation in patients with refractory epilepsy Felipe Fregni, MD, PhD; Sigride Thome-Souza, MD; Michael Nitsche, MD; Steven Freedman, MD, PhD; Kette Valente, MD, PhD; Alvaro Pascual-Leone, MD, PhD; Harvard Center for Noninvasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA Department of Clinical Neurophysiology, Georg-August University, Goettingen, Germany Department of Clinical Neurophysiology, University of Sao Paulo, Brazil Running title: DC stimulation in patients with epilepsy Corresponding author: Felipe Fregni, MD, PhD – Harvard Center for Noninvasive Brain Stimulation - Harvard Medical School - 330 Brookline Ave – KS 452, Boston, MA 02215 Email: ffregni@bidmc.harvard.edu, Phone: (617) 667-5272 Key words: Transcranial direct current stimulation, EEG, epilepsy, malformations of cortical development Acknowledgments This work was supported by a grant from the Harvard Medical School Scholars in Clinical Science Program (NIH K30 HL04095) and by K24 RR018875, RO1-NS 47754, RO1-NS 20068 to A.P.-L. This study was designed and planned in the Harvard Medical School, University of Sao Paulo and Georg-August University; and conducted in the University of Sao Paulo. Fregni et al. 2 Abstract Purpose: To study the safety of transcranial direct current stimulation (tDCS) in patients with refractory epilepsy and malformations of cortical development (MCD) as indexed by seizure frequency and epileptiform EEG discharges. Methods: Nineteen patients with MCD and refractory epilepsy underwent one session of cathodal stimulation (20 minutes, 1mA) targeting the epileptogenic