氟伐他汀与辛伐他汀调脂疗效、安全性.pdfVIP

药物与临床 Drugs and Clinic 氟伐他汀与辛伐他汀调脂疗效、安全性 及经济学比较的系统评价 张春燕，任晓蕾，刘一，黄靖，陈月，冯婉玉* 北京大学人民医院药剂科，北京 100044 [摘要] 目的：系统评价氟伐他汀与辛伐他汀调脂作用的有效性及安全性。方法：采用循证医学的文献分析评价方法，计算机 检索Cochrane 图书馆、Pubmed 、EMbase 、中国生物医学文献光盘数据库、中国期刊全文数据库、维普中文科技期刊、万方数 字化期刊群等数据库，全面收集氟伐他汀与辛伐他汀调脂作用的有效性和安全性的随机对照试验。评价纳入研究的方法学质 量，提取有效数据，采用RevMan 5.1软件对数据进行Meta分析。结果：检索到辛伐他汀和氟伐他汀调脂作用的有效性及安全 性的随机对照试验共16篇，其中中文文献11篇，英文文献5篇。辛伐他汀在降低TC及TG水平方面显著优于氟伐他汀，辛伐他 汀在降低LDL水平及升高HDL水平方面也具有优势，经济学评价结果同样显示辛伐他汀具有优势，安全性评价结果显示两组 治疗方案安全性相当。结论：辛伐他汀调脂疗效优于氟伐他汀，安全性与氟伐他汀相当，经济学方面具有明显优势。但由于 纳入的研究数量有限，该系统评价的结果需谨慎对待，尚需更多的设计合理、多中心、大样本的RCT 以进一步证实。 [关键词] 氟伐他汀；辛伐他汀；调节血脂；有效性；安全性；经济学；系统评价 [中图分类号] R973　　[文献标识码]　A　　[文章编号]　1672-2809(2015)10-0013-12 Systematic Review of Efficacy, Safety and Economics of Fluvastatinvs Simvastatin in the Treatment of Hypercholesterolemia ZHANG Chun-yan, REN Xiao-lei, LIU Yi, HUANG Jing, CHEN Yue, FENG Wan-yu Department of pharmacy, Peking University People ’s Hospital, Beijing 100044, China [Abstract] Objective: To evaluate the efficacy, safety and economics of fluvastatin and simvastatin in the treatment of hypercholesterolemia. Methods: Literature analysis based on evidence-based medicine was performed. Computer retrieval was conducted to search for randomly controlled trials on the impact of fluvastatin and simvastatin on anti- hypercholesterolemia efficacy, safety and economics. The quality of included studies was evaluated. Data were extracted into a specially designed extraction form. The Cochrane collaboration ’s RevMan5.1 software was used for data analysis. Results: The meta-analysis of 16 included RCTs showed that simvastatin treatment was associated with significantly greater reductions in TC, TG and LDL and increases in HDL. Simvastatin has greater superiority in cost-effectiveness compared with fluvastatin. Conclusion: It has been demonstrated that si