268例子宫内膜癌淋巴结转移相关因素分析.PDFVIP

998 Tianj in Med J, Oct 20 12, Vol 40 No 10 doi:10.3969/j.issn.0253-9896.2012.10.008 268 例子宫内膜癌淋巴结转移相关因素分析 李 艳 岳天孚 摘要 目的 探讨影响子宫内膜癌淋巴结转移的相关因素袁为制定手术方案提供依据遥 方法 收集经病理学证 实的 268 子宫内膜癌患者的临床病理资料并进行回顾性分析遥 根据患者淋巴结转移情况分为淋巴结转移阳性 组和阴性组袁分析 2 组肌层浸润尧病理类型尧宫旁受累情况尧分化程度尧年龄尧腹腔细胞学结果及血清CA125 水平的 异同袁并对上述指标 淋巴结转移之间的关系进行分析遥 结果 268 例子宫内膜癌的淋巴结转移率为 10.07% 渊27/ 268 冤袁主要转移至髂外淋巴结和闭孔淋巴结渊占81.48%冤袁腹主动脉旁淋巴结转移率为9.68% 渊6/62 冤遥 淋巴结转移 率在深肌层浸润尧非内膜样癌尧中分化和低分化内膜样癌尧累及宫颈或宫旁组织尧血清CA125 水平升高及年龄逸60 岁的患者均分别显著高于无肌层和浅肌层浸润尧子宫内膜样癌尧高分化内膜样癌尧仅限于宫腔内尧血清CA125 水平 正常及年龄60 岁的患者渊均P 0.01 冤袁而腹腔细胞学阳性 阴性者淋巴结转移率差异无统计学意义遥 多因素分 析结果表明内膜样癌分化程度尧肌层浸润和血清CA125 水平是淋巴结转移的影响因素渊均 P 0.05 冤遥 结论 深肌 层浸润尧中低分化子宫内膜样癌和较高的血清CA125 水平可作为淋巴结转移的高危因素遥 关键词 子宫内膜肿瘤 淋巴转移 淋巴细胞, 肿瘤浸润 CA-125 抗原 危险因素 病理学袁临床 回顾性研究 Analysis of the Related Factors of Lymph Node Metastasis in 268 Cases of Endometrial Carcinoma LI Yan 袁YUE Tianfu The Ge ne ral Hospital of Tianj in Medical Univ ers ity, Tianj in 300052, China Abstract Obj ective: To investigate the related clinical and pathological factors of lymph node metastasis in patients with endometrial carcinoma. Methods: A total of 268 patients with histological confirmed endometrial carcinoma were selected and retrospectively analysed. Patients were divided into two groups on the basis of positive or negative lymph nodes metastasis. The differences of the following parameters were compared between two groups, including depth of myometrial invasion, pathological type, para-uterus invasion, differential degree of endometrioid carcinoma, age, the result of abdominal cytology and se