实验动物医学(2015版本).ppt

减少非糖尿病小鼠产生I型糖尿病的几率 Persistant MHV （mouse hepatitis virus）infection reduces the incidence of diabetes mellitus in the non- obese diabetic mice，S Wilberz et al.,1991. 肝细胞吞饮功能丢失/下降。 肝脏酶活性改变。 诱生肝脏促凝血物质及甲胎蛋白。 其他病原的易感性、抵抗力及致病性改变。 五、病理变化 （二） 治疗肿瘤 Zhang, Q*., Xu, X., Yuan, Y., et al. IPS-1 plays a dual function to directly induce apoptosis in murine melanoma cells by inactivated Sendai virus. Int. J. Cancer, 2014，134:?224–234 ZHANG Q*, YUAN W F, ZHAI G Q, et al. Inactivated Sendai virus suppresses murine melanoma growth by inducing host immune responses and down-regulating β-catenin expression. Bi