医学毕业胃肠道肿瘤患者外周血中ss，tnf.docxVIP

XX大学 毕业论文 肠道肿瘤患者外周血中SS, TNF 姓 名： 2014年6月25日 胃肠道肿瘤患者外周血中SS, TNF 【关键词】 肿瘤坏死因子 Clinical significance and assay of peripheral blood somatostatin, TNFa，IL6, sIL2R in patients with gastrointestinal cancer [Abstract] AIM: To observe the changes of peripheral blood somatostatin (SS), tumor necrosis factora (TNFa), interleukin6 (IL6) and soluble interleukin2 receptor (sIL2R) levels in patients with gastrointestinal cancer. METHODS: The subjects were divided into 4 groups: 23 cases in normal control group, 37 patients in gastric cancer group, 23 patients in colon carcinoma group and 29 patients in rectal cancer group. The levels of TNFa, IL6 and sIL2R were assayed with ELISA and SS was assayed with RIA. RESULTS: Compared with that in control group, the level of SS decreased significantly in gastric cancer group, colon cancer group and rectal cancer group, but the serum levels of IL6 and sIL2R increased remarkably. The levels of IL6 and sIL2R were significantly different in the 3 types of gastrointestinal cancer (P0.05). Significant difference was found in the level of TNFa when control group and gastric cancer group were compared with colon and rectal cancer groups (P0.05). CONCLUSION: The detection of the changes of peripheral blood SS, TNFa, IL6 and sIL2R is of some clinical significance in the diagnosis and differentiation of patients with gastrointestinal cance匸 【Keywords ] neoplasms, gastrointestinal; somatostatin; tumor necrosis factor; interleukin; receptor 【摘要】目的：观察胃肠道肿瘤患者外周血生长抑素(SS)、肿瘤坏死因 子a (TNFa)、白介素6 (IL6)、可溶性白介素2受体(sIL2R)表达水平的变化. 方法：正常对照组23例，胃癌组37例，结肠癌组23例，直肠癌组29例.放射 免疫法(RIA)检测SS, ELISA法检测TNFa, IL6和sIL2R水平.结果：与对照组 相比，胃癌组、结肠癌组、直肠癌组SS水平明显降低，而血清屮IL6, SIL2R水 平则明显升高(P0.05),且后两者在三种类型的胃肠道肿瘤间显示组间差 (P0.05)；结肠癌组、直肠癌组TNFa与对照组及胃癌组间差别有显箸性(P0.05). 结论：检测血液中SS, TNFa, IL6和sIL2R对胃肠道肿瘤的诊断有一定的意义 【关键词】肿瘤，胃肠道；生长抑素；肿瘤坏死因子；白介素；受体 0引言 肿瘤患者多有免疫功能的异常，常伴有免疫抑制因子的表达升高或(和)免 疫促进因子表达水平的降低.研究表明患者外周血中生长抑素(somatostatin, SS)、肿瘤坏死因子a (TNFa)、白介素6 (IL6)、可溶性白介素2受体(sIL2R) 等水平变化与肿瘤相关，但结果不统一；探索多种细胞因子与肿瘤发