rhPTH(1-34)对兔下颌骨牵张成骨作用的实验分析.pdfVIP

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rhPTH(1-34)对兔下颌骨牵张成骨作用的实验分析.pdf

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Abstract Effect of rhPth(1-34) Walker on mandibular distraction osteogenesis in rabbits The Fourth Affiliated Hospital of Zhengzhou University Abstract Objective ： To study the effect of rhPTH(1-34) on promoting bone formation on mandibular distraction osteogenesis （DO ）in rabbits , so as to provide foundation for its clinical application of rhPTH(1-34) in the field of DO. Material and Methods ： 8 big-eared Japanese Rabbits （no sex limit ,weights about 2.0-2.5Kg ）were selected as experimental animals,which were randomly dividedinto the control group,the rhPTH(1-34)12.5μg/kg group, the rhPTH(1-34)25μg/kg group, and the rhPTH(1-34)50μg/kg group,with ten rabbits in each group. Their parts ahead next to premolar teeth and mental foramen area on the right side of the mandibulars were slited in order to establish unilateral mandibular distraction osteogenesis models. Distraction was started one week after surgery at the rate of 0.4mm/12h, which continued for 10 days, extending mandibular by 8.0mm and followed by fixed period. The corresponding dose of rhPTH(1-34),dissolved in 2% heat inactivated standard rabbit serum 1 ml, was given at eight every day via subcutaneous injection to the experimental groups from the distraction period till the rabbits’ death whlie the control group was only given 2% heat inactivated standard rabbit serum 1 ml at the same time every day. Five rabbits from each group were executed at the f