地塞米松对家兔复张性肺水肿的预防作用-外科学(心胸外)专业论文.docxVIP

贵阳医学院 贵阳医学院 2011 届硕士研究生论文 1 1 地塞米松对家兔复张性肺水肿的预防作用 专业：外科学(心胸外) 研究生：杜小军 导师：肖家荣 袁世璋 【摘要】目的：通过研究地塞米松对家兔复张性肺水肿的预防作用进而推断其在 临床上是否对复张性肺水肿具有预防作用。方法：按照一定方法建立家兔肺压缩 模型，维持肺压缩 7 天后复张压缩肺。实验组肺复张前 30 分钟静脉推注一定剂 量地塞米松；对照组肺复张前 30 分钟静脉推注相应剂量的生理盐水。1 小时后 经双侧胸腔取双侧肺组织并称量。恒温箱中干燥 48 小时后称量肺标本干重并做 统计分析。结果：对照组右肺湿干比为 5.483±0.611；实验组右肺湿干比为 4.723 ±0.416，p=0.007，差异有统计学意义。结论：地塞米松对复张性肺水肿有预防 作用，高风险人群可以先静脉推注（或滴注）适量地塞米松以减小复张性肺水肿 的发生几率。 【关键词】复张性肺水肿 家兔 地塞米松 预防作用 14 14 Preventive effect of dexamethasone on Reexpansion Pulmonary Edema in rabbits Yuan Shizhang Xiao Jiarong Du Xiaojun Department of Thoracic Surgery, the First Affiliated Hospital of GuiYang Medical College, GuiYang GuiZhou, 550004 Abstract Objective: To study the protective effect of dexamethasone on reexpansion pulmonary edema in rabbits to deduce whether dexamethasone has the ability to protect human beings against reexpansion pulmonary edema(RPE) or not clinically. Method: The right lungs were collapsed for 7 days artificially by some way before reinflation. Rabbits in experimental group were injected some dosage of dexamethasone 30min before reinflation while those in control group were injected propotional dosage of normal sodium. Then bilateral lungs were taken out for weight 1 hour after the right lungs were reinflated. And all lungs were dried for 48 hours before weighing. Then statistical analysis was done. Result: The wet-to-dry weight ratio in the control group was 5.483± 0.611 to 4.723± 0.416 in the experimental group, P=0.007, which had statistical significance. Conclusion: Dexamethasone can protect rabbits against reexpansion pulmonary edema efficiently. So, dexamethasone should be used on patients who are in high risk to reduce the incidence of RPE edema and benefit patients. [Key words]: Reexpansion pulmonary edema; Rabbits; Dexamethasone; Preventive effect PAGE PAGE 16 略缩词表 缩写 英文名称 中文名称 RPE Reexpansion pulmonary edema 复张性肺水肿 ALI Acute lung injury 急性肺损伤 ARDS Acute respiratory distress syndrome 急性呼吸窘迫综合征 ROS R