包礼scfor昊mulations水悬浮剂.ppt

SC formulations 水悬浮剂 Suspension Concentrates 海利尔农药论坛（第十届山东省农药信息交流会） 英国禾大公司 www.C SC 水悬浮剂 描述：固体颗粒悬浮于水中 Description: Solid particles suspended in water 常见问题Issues 悬浮物质与水之间存在密度差 Density difference between suspended matter and water 如果原药密度大于1克/毫升将形成沉淀 Will form sediment if density is 1 如果原药密度大于1克/毫升将漂浮 Will float if density is 1 根据斯托克斯定律：较小的粒径是必须的 Stokes law: small particles are required 怎样获得较小的粒径 How to obtain small particles? 怎样保持粒子的悬浮稳定性 How to keep the particles suspended? 结晶增长Crystal growth Formulation breakdown processes制剂被破坏的过程 Oswald ripening奥氏熟化 A.I. has limited water solubility 原药在水中有一定的溶解度 Solubility of small particle is higher than solubility of large particle 较小粒经的溶解度大于较大粒经的溶解度 How to prevent Oswald ripening怎样预防奥氏熟化的发生 较窄的粒径分布范围 Narrow particle size distribution 还有其他的诀窍 There are other tricks: Very limited amount of diluted oil in aqueous phase 将一定量的油稀释到水相中 To make an SC 水悬浮剂制备 Preparation of small particles 小粒子的制备 Preventing flocculation Preventing sedimentation To make an SC 水悬浮剂制备 Preparation of small particles 小粒子的制备 Small suspended particles are prepared by milling process 通过砂磨设备获得较小粒径 Processing conditions are important 生产工艺条件很重要 To make an SC 水悬浮剂制备 Preparation of small particles 小粒子的制备 Wetting - Dispersion - stabilization润湿 —?分散 —?稳定性 Issue during milling process砂磨过程中出现的问题 During milling process fresh surface is generated 砂磨过程中新的粒子表面产生 Fresh surface is generally of non-polar nature en will cluster together rapidly 新产生的非极性的表面通常是的自然对开很容易迅速聚集 This could lead to increased viscosity and even mill blockage 这可能导致粘度增加甚至阻碍砂磨进程 To overcome mill blockage a wetting agent is needed 为了克服这一问题所以润湿剂的加入是非常必要的 To make an SC 水悬浮剂制备 Preparation of small particles Preventing flocculation 絮凝的预防 Preventing sedimentation How to prevent flocculation? 怎样预防絮凝的产生 Use of dispersants 分散剂的使用 Dispersant should be firmly locked on substrate Anchoring 锚