度拉糖肽治疗2型糖尿病的有效性和安全性系统评价-药剂学专业论文.pdf.docxVIP

率、13细胞功能等疗效指标上的改变明显优于安慰剂，两者间的差异具有 率、13细胞功能等疗效指标上的改变明显优于安慰剂，两者间的差异具有 统计学意义。度拉糖肽治疗2型糖尿病时的总不良反应发生率与安慰剂比 较无统计学差异，严重不良反应罕见。说明度拉糖肽与安慰剂比较，能有 效控制2型糖尿病患者的血糖水平，而且安全性高，患者耐受性好。 关键词：度拉糖肽；安慰剂；2型糖尿病；系统评价；meta分析 万方数据 Effectiveness Effectiveness and Safety of Dulaglutide for Treatment of Type 2 Diabetes：a Systematic Review Abstract：Objective：To evaluate the efficacy and safety of dulaglutide (Trulicity,LY2 1 89265)for the treatment of type 2 diabetes mellitus and provide evidence for clinical practice．Methods：Randomized controlled trials(RCTs) of dulaglutide versus placebo for treatment of ty’pe 2 diabetes were searched in PubMed，Cochrane Library，Medline，Embase，ClinicalTrails．gov，CNKI， WanFang and VIP．Meta—analysis was performed by using RevMan 5．3．0 software．AU of the databases were searched from the date of their establishment to December 28，20 1 5．Search terms are dulaglutide，Trulicity, LY2 1 89265，placebo，type 2 Diabetes，T2DM，randomized controlled trial， meta-analysis，systematic review,etc．According to the way of the Cochrane systematic review,two researchers firstly defined the inclusion criteria and exclusion criteria，then viewed the literature，extracted data and assessed quality of the literature independently,finally unified data after cross-checking， perform meta—analysis by using RevMan 5．3．0 software．Results：6 RCTs involving 2265 patients were included．Interventions of 6 RCT studies behaved slightly different．Patients of the treatment group received subcutaneous injections of once—weekly dulaglutide 0．75mg，control group was given subcutaneous injections of once-weekly placebo 0．75mg treatment in 4 RCTs． In 4 RCTs patients of the treatment group received subcutaneous inj ections of once．weekly dulaglutide 1．5mg，control group was given subcutaneous 4 万方数据 injections injections of once-weekly placebo 1．5mg treatment．Reviewer evaluated the including RCTs’risk of bias according to the Cochrane Manual 5．0．1 recommended t001．The results showed lOW risk of bias for 6 st