医学微生物学课件--吴第32章朊粒.pptVIP

医学微生物学 * Chapter 32 朊粒(Prion)仅有蛋白质, 无核酸多beta折叠, 对蛋白酶的抗性引起人库鲁病, 克-雅病 Cellular prion protein (PrPc) can be identical to scrapie like prion protein(PrPsc) in its protein sequence but differs in tertiary structure. PrPc PrionPsc Simplified model for prion disease. PrPsc, acts as a template. It associates with the helical form allowing the latter to be converted to the beta-pleated sheet resistant form There are now two molecules of the resistant form that can act as a template and so the process accelerates PrionPsc的抵抗力PrP抵抗力强，对甲醛，戊二醛，乙醇，蛋白酶, 标准高压灭菌法等具有抗性。可用以下方法灭菌:1N NaOH 1h, then